The differences in homeostasis model assessment values in type 2. Betacell function estimated with the homa index and insulin sensitivity with fasting glucose. These will depend on the specific assays used for glucose, insulin and cpeptide. Comparison of a patients fasting values with the models predictions al lows a quantitative assessment of the contributions of insulin resistance and deficient r cell function to the fasting hypergly caemia homeostasis model assessment, homa. The homa calculator is a tool for assessing the insulin sensitivity %s and beta cell function %b, for professionals in the health care field. Matsuda insulin sensitivity index for oral glucose tolerance tests isogtt and homeostasis model assessment of insulin resistance homair. The homa of insulin resistance homair index, the product of basal glucose and insulin levels divided by 22. Insulin sensitivity and insulin secretion determined by. The index is a quantitative, convenient, and accurate tool in analyzing epidemiologic data and identifying incipient impaired glucose tolerance. Height, weight, waist and hip circumference, body mass index bmi, blood. Ir as assessed by homa indices has also been correlated with intimamedia thickness of the carotid artery 9 which is a wellaccepted marker of. Women with gestational diabetes have an insulin response similar to that of normal volunteers. Study of betacell function by homa model in metabolic syndrome article pdf.
Homeostatic model assessment homa is a method for assessing. Interpretation of homa indices university of oxford. Association of vitamin d with insulin resistance and betacell. Indices of betacell function, but neither insulin sensitivity nor fasting. Interpretation of homa indices there is no absolute value for homa indices. Beta was used to predict secretory capacity of pancreatic beta.
These gave approximate values of %b and, instead of %s, homa ir insulin resistance which is the reciprocal of %s 100%s. It has been reported in 500 publications, 20 times more frequently for the estimation of ir than. Insulin secretion beta cell function was also obtained from fasting samples, as homa. This program can assist you in managing type 2 diabetes, but not by replacing a formal medical assessment. Assessment of insulin sensitivity and betacell function from. The calculator uses the homa2 model for its estimation of %s and %b. The equations have been used widely, particularly for estimates of beta cell function and insulin resistance in largescale studies, but are not appropriate for use with currently available insulin assays. At any given time, insulin secretion depends on the level of insulin resistance. In addition, optimal diagnostic cutoffs for irrelated conditions seem to vary considerably from one population or group to the next so care should.
Hence, we studied betacell function, as assessed by homa model, in subjects with ms. The homair score may be most useful for epidemiologic, populationbased, and other group level assessments. Compared with that in other diabetic patients, homa. The normal homa ir value of healthy human ranges from 0. Determination of insulin resistance and betacell function using. We studied 50 subjects with ms diagnosed by idf criteria and 24 healthy age and sexmatched controls. Homair scores statistically significantly influence the odds that t2dm is diagnosed.
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